Abstract
The 5′-flanking region of human γ-glutamylcysteine synthetase-heavy subunit (γ-GCS-HS) was characterised by creating a series of chloramphenicol acetyl transferase (CAT) reporter deletion constructs. Analysis of various deleted CAT constructs revealed that a putative AP-1 consensus sequence is required to direct the constitutive and oxidant-mediated promoter activity. Gel mobility shift and mutation analysis of the sequence (−269 to −263 bp), showed binding of AP-1 is involved in the oxidant-mediated regulation of γ-GCS-HS promoter activity.
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