Abstract
Publisher Summary This chapter discusses three viruses that have been primarily responsible for respiratory infections in mice: Sendai virus, pneumonia virus of mice (PVM), and κ virus. Each virus is distinct in its epizootiology, serology, and pathogenesis. Only Sendai regularly produces clinical disease, PVM is latent but produces widespread subclinical infection, and κ virus—also latent—is infrequently encountered. The epizootiology of Sendai and PVM is complicated by the fact that these viruses cross-infect different laboratory animal species—notably the mouse, hamster, rat, and guinea pig. The likelihood of epizootics is increased by mixing animals from different sources. Traditionally, this problem has been addressed by attempting to carefully select animals from colonies without infections—or as a compromise, with similar infections—and to mix these animals carefully into the laboratory colony through a variety of quarantine procedures. Efforts by breeders to eliminate these virus infections from their colonies have been only partially successful.
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