Abstract
The lung is protected by multiple mechanisms, but the primary defense is mucociliary clearance (MCC). MCC is responsible for removing noxious particulates that may reduce lung health, but it can also clear inhaled pharmaceuticals. Effective MCC relies on the correct ciliary structure and pattern of movement, combined with mucus rheology characteristics, that together facilitate particle capture and transport. Abnormalities in these result in muco-obstructive disease.
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