Abstract
To accomplish brain delivery of therapeutics, multifarious nanoparticles (NPs) have long been used through various routes of administration. Among the various routes of administration, nasal delivery has been found to be of considerable importance in the delivery of therapeutics and therapeutic-loaded NPs preferably to the central nervous system. This chapter discusses plethora of methods used to design NPs to enhance nasal delivery of therapeutics such as drugs and peptides. Surface functionalization of NPs with mucoadhesive chitosan and its derivatives has been explained. In addition, molecular underpinnings entailed in enhanced brain delivery of intranasally delivered therapeutics and therapeutic-loaded NPs and their efficacy in treating Parkinson's disease have been highlighted. It also emphasizes a few demerits of both nasal delivery and NPs mediated nasal delivery.
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