Abstract
This chapter provides an overview of species differences in the anatomy and physiology of the gastrointestinal system among rodents, dogs and primates, emphasizing that the dog is a good model for functional aspects of the human gastrointestinal tract. It describes and discusses the human relevance of drug-induced changes in the mouth, oropharynx, teeth and salivary glands of laboratory animals. It describes the pathology that can be seen in the esophagus. It discusses changes that can be seen in the rodent forestomach and their usual but incomplete lack of relevance for humans. Spontaneous and drug-induced inflammatory and proliferative disorders found in the stomach, small and large intestines are described in detail particularly those that result from treatment with non-steroidal anti-inflammatory drugs and anticancer therapies. It also discusses the relevance of gastrointestinal neoplasms that may be found in rodents following treatment with therapeutic agents.Keywordsmouth, oropharynx, salivary glands, esophagus, forestomach, glandular stomach, small intestine, large intestine, drug safety, comparative pathology, neoplasia
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
