Abstract
This chapter gives a brief account of the anti-ulcer properties of tea. Our findings on the protective property of black tea (BT) and the theaflavins (TF) against indomethacin-induced stomach ulceration in mice are also described, along with a discussion of the mechanism of action. Indomethacin (18 mg/kg, p.o. ) administration induced maximum ulceration in the glandular portion of the gastric mucosa on the third day, accompanied by depleted plasma total antioxidant status, reduced expressions of cyclooxygenases, and prostaglandin synthesis, and reduction of eNOS/iNOS ratio in the gastric tissues as well as increased nitrite level and myeloperoxidase activity. Treatment with BT (30 mg/kg) and TF (0.5 mg/kg) and omeprazole (3 mg/kg) prior to indomethacin administration prevented the ulceration, as revealed in histopathological studies. The designated biochemical parameters were also reversed by the test samples, without modulating acid secretion.
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