Abstract
Clinicians occasionally measure the blood level of a drug and use that information to modify the drug dosing schedule. However, taking blood samples is an invasive procedure that can have dire consequences such as psychological trauma or iatrogenic infection. With the significant costs linked to the collection and analysis of blood samples (e.g., emolument for phlebotomists, nurses, and lab technicians), clinicians and researchers are investigating substitute biomatrices for therapeutic drug monitoring. Traditional therapeutic drug monitoring techniques possess certain practical disadvantages in the context of large-scale practice such as long turnaround times, lack of standardization in workflows, and high cost of analytical equipment with complicated sample preparation steps. Recently, the use of microneedles has generated interest as a substitute approach for therapeutic drug monitoring. In this chapter, the use of microneedles for therapeutic drug monitoring will be discussed.
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