Abstract
Breast cancer is the most commonly diagnosed cancer among women worldwide. Although the main pathways in tumor progression are not clarified, early diagnosis and efficient treatment of breast cancer can improve survival. Current breast cancer treatment involves surgery, chemotherapy, radiation, endocrine therapy, monoclonal antibody therapy, and immunotherapy; however, these therapies frequently cause adverse effects. Folate receptor is overexpressed in several types of cancers such as breast, ovarian, lung, and uterine cancers, and it has been extensively studied for developing actively targeted chemotherapeutics and diagnostics. Many researchers have made an effort in developing folate-targeted nanomedicines and theranostics and applying them in clinics. This chapter reviews recent folate-targeted nanomedicines for breast cancer chemotherapy with an emphasis on in vitro and in vivo studies.
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