Abstract
Publisher Summary Studies have been performed showing the presence of ATP responses in several chick tissues including ciliary ganglia neurons (Abe et al ., ), isolated skeletal muscle myocytes, and cardiac myocytes (Kolb and Wakelam,; Podrasky et al .,). The chapter describes the cloning and functional characterization of a new P2X subunit isolated from embryonic chick brain. The corresponding protein is highly homologous to the mammalian P2X 4 receptor subtypes (human and rat) with approximately 75% sequence identity to both subunits. Chick P2X 4 (chP2X 4 ) transcripts are present in both brain and heart embryonic tissue during development. The functionality of chP2X 4 receptor was assayed by heterologous expression in Xenopus laevis oocytes, a system that has been successfully used to describe the mammalian P2X receptors. The homomeric receptor shows functional properties that are similar to rat and human P2X 4 , with slight differences in sensitivity to ATP and suramin.
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