Abstract
This chapter discusses cellular immune response in viral infections. Cellular immunity plays a role in the defense against certain viral infections. First, it is known that certain viruses, such as herpes simplex, can persist in vivo and in vitro in the presence of high concentrations of neutralizing antibody. Second, from experiments of nature, it has been shown that patients with deficiencies in cellular immunity have difficulty in coping with certain viruses, such as herpes simplex, cytomegalo, varicella zoster, measles, and vaccinia, but do not have difficulty with a number of other common viral infections, such as polio. Third, experiments in animals have shown that suppression of the cellularimmune response by neonatal thymectomy or antilymphocyte serum makes animals more susceptible to only certain viruses. Fourth, if both cellular-and humoral-immune responses are experimentally suppressed in animals by cyclophosphamide, reconstitution with antibody can prevent death by viruses such as Coxsackie or encephalomyocarditis, but immune cells are needed to protect against other viruses such as mousepox.
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