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Abstract
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide. Although the survival statistics for some cohorts with this type of cancer are improving, there is still a need to find biomarkers that allow early diagnosis. One of the emerging molecules that can meet this niche are microRNAs (miRNAs), small single-stranded noncoding RNA molecules expressed in all tissues. There is a growing interest in microRNA-related single nucleotide polymorphisms (miRNAs-SNPs), which could be associated with susceptibility to cancer, including head and neck cancers (HNC). These miRNA-related SNPs could serve as novel, low-invasive genetic biomarkers for the early detection of susceptible individuals. In the present chapter, we thoroughly reviewed different SNPs, which were investigated for a potential correlation with the HNC risk.
Published Version
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