Abstract
This chapter focuses on identification and functional analysis of genes and genetic risk factors in Alzheimer's disease. The chapter illustrates that although it is widely recognized that AD is a complex disorder of the CNS in which many genetic and environmental factors influence the pathogenesis, molecular genetic analysis of AD has provided with major breakthroughs in the unraveling of the molecular causes for this dementia. With the identification of genes and genetic risk factors, the knowledge about the biochemical processes underlying this disease gradually continues to grow as well. Knowledge about the biological function and dysfunction of genes involved in AD, although still fragmentarily, may lead to understanding the primary disease mechanisms. This in turn can help to develop a more efficient therapy that can either decelerate or cure this devastating disorder of human mind.
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