Abstract
The introduction of next generation sequencing (NGS) technology to clinical and experimental oncology rapidly changed our understanding of the complex landscape of cancer genetics. NGS-based studies brought significant discoveries of new mutations in most common cancers as well as in orphan diseases. However, there are several issues that need to be resolved before wide application of NGS to clinical settings. This chapter briefly outlines major issues related to the current and future application of NGS in clinical oncology. Challenges related to tumor heterogeneity and possible application of NGS in treatment monitoring as well as application of NGS to detect circulating tumor DNA, including circulating cell-free DNA, are also described.
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