Abstract
This chapter highlights key findings concerning the assembly of silent chromatin and the regulation of silent chromatin spreading in budding yeast, focusing on the function of Sir proteins in silencing. In particular, the proteins and histone modifications that positively influence silent chromatin formation or restrict silent chromatin spreading are discussed. In Saccharomyces cerevisiae (S. cerevisiae) or budding yeast, silent chromatin is cytologically distinct from heterochromatin in other eukaryotes, but many of the proteins and histone modifications involved are conserved through humans. In particular, the process of silent chromatin formation and its regulation in yeast has led to an increased understanding of how chromosomal position can affect gene expression. Numerous proteins have been implicated in silencing, linking diverse cellular processes to silencing, including cell cycle progression, DNA repair, and DNA replication, among other functions. Sir proteins themselves have also been implicated in other processes, including aging, chromosome stability, DNA repair, and DNA replication. Many recent studies have addressed the establishment and maintenance of silent chromatin and the control of silent chromatin spreading. Histone modifications and histone modifying enzymes have been identified that are required for promoting or restricting silent chromatin spreading.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
