Abstract
Cancer cachexia remains an unsolved clinical problem. This syndrome is associated with muscle and adipose tissue wasting, anorexia, systemic inflammation, and major metabolic disruption. All these symptoms compromise cancer treatment outcome, quality of life, and survival. Fish oil supplementation has been found to attenuate some of the consequences of cachexia, as reported in animal models and patient trials. The potential of marine omega three fatty acids to counteract cachexia-related weight and appetite loss, and to modulate peripheral inflammation and metabolism are discussed, along the recently proposed roles in neuroinflammation. Fish oil supplementation appears as a promising strategy in adjuvant cachexia treatment.
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