Abstract
The development of peptide-based vaccines has increased dramatically in the past several years, resulting in one of the most economical and effective vaccine strategies. The use of peptides has advanced the delivery, stability, and design of vaccines in comparison to traditional nonpeptide-based vaccines. Peptides as epitopes alone are poor immunogens and thus require an immune stimulant to boost the immune response. Further, limited bioavailability and low immunogenicity have been obstacles overcome in the development and design of peptide-based vaccines. To overcome these caveats, peptidomimetics have been designed by chemical alteration of peptides and their structure to improve immunogenicity and stability for more efficient vaccines. This chapter briefly summarizes the developments in the field of peptide- and peptidomimetic-based vaccines and also discusses the advantages and disadvantages associated with these vaccines.
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