Abstract

The present chapter aims to describe the strategies involved in synthesis and functionalization of chitosan-built nano-hydrogel as smart drug carrier for various cationic, anionic, hydrophilic, and hydrophobic drugs at the physiological condition. An overview of nano-hydrogel processing, the desired surface-modification or induced sensitivity (induced hydrophilicity, hydrophobicity, glucose-sensing, and self-assembling) with respect to selective anionic/cationic drug loading and release mechanisms is highly stressed to discover the art of in-situ gelling system. The art of various chitosan-built nano-hydrogel and their structure–property-relationship is explained to support and establish the fact that, chitosan is the most promising biomaterial to be applied for various pharmaceutical and biomedical applications, particularly as a smart drug carrier for a variety of cationic and anionic (hydrophilic/hydrophobic) drugs.

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