Abstract
Publisher Summary This chapter discusses various advantages of supercritical fluid chromatography (SFC) over gas chromatography (GC) and high-performance liquid chromatography (HPLC) and also provides some interesting applications. SFC employs supercritical fluid instead of gas or liquid to achieve separations. Supercritical fluids generally exist at conditions above atmospheric pressure and at an elevated temperature. As a fluid, the supercritical state generally exhibits properties that are intermediate to the properties of either a gas or a liquid. The density of a supercritical fluid approaches the levels of a liquid as does its diffusivity, while its viscosity is similar to that of a typical gas. These properties offer rapid movement (equilibration) as in a gas, but solvation or solubilization as found in a liquid. In SFC, fluids above their critical point are used as mobile phases. The use of supercritical fluids to separate enantiomers is one of the most important tasks in several areas of research, especially pharmaceuticals and agrochemicals.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
