Abstract
In 1991, solid lipid nanoparticles emerged as a substitute to conventional colloidal carriers (polymeric nanoparticles, liposomes, niosomes, and nanoemulsions). Solid lipid nanoparticles merge the advantages of conventional colloidal carriers, yet overcome some of their drawbacks. Moreover, these nanoparticles have prospective applications in research, the pharmaceutical field, clinical medicine, cosmetics, and other allied sciences. In recent times, more attention has been paid to solid lipid nanoparticles as carriers for encapsulating lipophilic drugs. Antigens and proteins used for therapeutic purposes can be encapsulated in solid lipid nanoparticles and administered through oral, pulmonary, parenteral, and nasal routes. This chapter reviews the present state of the art regarding production methods for solid lipid nanoparticles. The characterization, sterilization, and toxicity of the prepared nanoparticles are also highlighted. The potential of solid lipid nanoparticles for drug delivery is highlighted.
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