Abstract
Non-coding RNAs (ncRNAs) are RNAs that are transcribed from DNA but not translated into protein. Based on their lengths, they have been classified into two classes (short and long) and are known to be involved in the epigenetic regulation of gene expression. ncRNAs also play a major role in the development and functioning of the brain. They have also been implicated in the pathogenesis of psychiatric disorders. This chapter describes the current state of knowledge of the roles of ncRNAs in the pathogenesis of psychiatric disorders, focusing on schizophrenia, bipolar disorder, and major depressive disorder. Most research to date on the role of ncRNAs in the pathogenesis of these disorders has centered around microRNAs (miRNAs). Determining the role that ncRNAs play in psychiatric disorders is in its very early stages, and further study is necessary to elucidate the precise ways in which their dysregulation leads to the development of psychiatric disorders.
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