Abstract
Publisher Summary This chapter discusses the interferon cell receptor interactions. The genetic analysis of the interferon system using somatic monkey-mouse hybrid cells demonstrated the discordant segregation of chromosomes involved in interferon synthesis and the antiviral state. Like insulin, interferon diffuses from the site of its production through the bloodstream of distant sites. Like some of the peptide hormones, interferon seems to interact with cell receptors located on the cell membrane and induces from there a series of events that lead to the antiviral state. The receptor-interferon interaction is probably of a cooperative type, which means that interferon induces configurational changes in the receptor leading to activation. Thus, the receptor system consists of at least two operational sites: the binding and the activator sites. Cooperative activation between receptor systems located at different sites on the cell membrane is also among the possibilities.
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