Abstract
Since the 1960s, ependymal cells facing the central canal of the spinal cord have been expected to differentiate into other cell types. Recent studies have proved that spinal cord ependymal (SCEp) cells really possess the properties similar to neural stem cells or glial progenitor cells; especially after spinal cord injury, they undergo massive proliferation and give rise to astrocytes in addition to their progenies. This chapter focuses on the recent progress of SCEp cell studies in terms of morphological heterogeneity in the intact condition and proliferation and differentiation potentials after injury. Also, the effects of extrinsic factors and intracellular signaling and transcription factors regulating the development and cell fate of SCEp cells, such as proliferation, migration, and differentiation, were summarized.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
