Abstract
The occurrence of human fungal infections, particularly from drug resistance-acquiring pathogenic yeast, has increased considerably and poses a major problem towards the implementation of successful fungal therapies. Efficient therapeutics is hampered by the emergence of drug resistance in fungi. Understanding the molecular pathways specific to yeast is essential for the development of strategies to combat multidrug resistance (MDR). Many signaling cascades in yeasts are yet to be exploited for therapeutic purposes. One such promising signaling pathway is the retrograde (RTG) signaling pathway. The mitochondrion is an essential organelle which performs many crucial functions in eukaryotic cells. Apart from energy production, the mitochondrion is also the site of various catabolic and anabolic reactions which contribute to intracellular signaling, aging, and formation of reactive oxygen species. In the present chapter, we have summarized the current knowledge on the retrograde signaling, activated by mitochondrial dysfunction. We also report on the connections between the RTG signaling pathway and other signaling pathways in yeast, such as the TOR signaling pathway.
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