Abstract
Publisher Summary This chapter discusses the mechanism of interferon-induced block in mRNA translation. Variations in tRNA populations from one type of cell to another may certainly explain why the sensitivity of different viruses to interferon varies from one cell type to another. Different mRNAs require the addition of different tRNA species to be translated in the interferon S10. For Mengo RNA, a minor Leu-tRNA species seems to be required. Lack of this tRNA stops polypeptide chain elongation and subsequently inhibits new initiation. The tRNA dependency of interferon S10 may be because of degradation of some tRNA species or to another mechanism that makes these tRNAs unavailable for translation. This has to be a rather specific mechanism as only certain species of tRNA are affected; it is relevant to note that T4 phage infection induces degradation of Leu-tRNA in E. coli.
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