Abstract
Abstract The relationships between classic and variant small cell lung cancer (SCLC) cell lines and between variant SCLC (SCLC-V) and non SCLC (NSCLC) cell lines has been explored using a panel of selected monoclonal antibodies (Moabs). The aims of this study were to identity cell surface antigenic phenotypes which characterise the various lung tumour types and to relate the expression of lung tumour antigens to differentiation status. These studies have identified antigenic phenotypes that (1) distinguish classic from variant SCLC cell lines; (2) distinguish SCLC (irrespective of subtype) from NSCLC; (3) correlate with the expression of L-dopa decarboxylase, neuron specific enolase and creatine kinase BB.
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