Abstract
Curcumin, a yellow hydrophobic polyphenolic compound with antioxidant, antiinflammatory, and anticancer properties, is found in the spice turmeric. Curcumin can be delivered to the body tissues through oral, nasal, intraperitoneal, and intravenous injections. Curcumin is remarkably well tolerated by the body, but its bioavailability in the body tissues is very low. There are three major reasons for the low bioavailability: (1) its poor absorption, (2) its rapid metabolism, and (3) its rapid systemic elimination. The bioavailability of curcumin can be enhanced by using adjuvant (piperine), structural analogs, chemical complexation agents, liposomes, and nanoparticles. These approaches have not only resulted in longer circulation and increase in the cellular permeability but also resistance against metabolic processing leading to efficient delivery to tissues and higher half-life in the circulation. Usefulness of curcumin analogs for the treatment of neurological disorders will be discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Curcumin for Neurological and Psychiatric Disorders
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
