Abstract
Application of transition metal-catalyzed CH activation reactions to natural product synthesis is an emerging and exciting area of research that not only obviates the need for prefunctionalization of the substrates, but also bypasses multistep sequences providing opportunities for designing new retrosynthetic paradigms. The key challenges associated with this field are the compatibility and selectivity issues with polyfunctionalized substrates. Palladium-catalyzed directed functionalization of CH bonds is gaining a lot of attention as a new synthetic strategy maximizing the atom- and step-economy, and has found application in the planned synthesis of many natural products and biologically active compounds. In this chapter, we aim to highlight the recent applications of palladium-catalysis for the synthesis of complex molecular frameworks wherein CH activation was employed as a key step.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Strategies for Palladium-Catalyzed Non-Directed and Directed C—H Bond Functionalization
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
