Chapter 12 - Peptide and Protein Application in Tissue Repair and Regeneration

Abstract

Several case studies are described in this chapter that present the application of peptide and protein drugs in various surgical techniques and medicines. The formulation of these drugs is relatively complex and draws on existing polymeric carriers for their delivery to a local site. This is interesting, since it is a move away from more familiar protein delivery systems which are generally based on subcutaneous or intravenous injection or polymer encapsulation technologies for controlled delivery (e.g., Zoladex Implant). It is therefore important to be aware of this class of medical devices, since it offers great potential for emerging biomaterials research to be translated into medical practice. The design of the formulation is clearly central to the method of application and will continue to draw on multidisciplinary research themes such as protein engineering, surface adsorption, polymer synthesis, protein–polymer interactions, etc. The outcomes of the human clinical trials have been vital to determining the scope and utility of these medical devices and play a clear role in directing the field. The clinical need for this class of medical devices will continue to grow as the field of regenerative medicine becomes ever more integrated into healthcare.