Abstract
This chapter presents a discussion on the role of magnetic resonance (MR) diffusion and perfusion imaging in epilepsy and discusses various techniques—such as perfusion and diffusion-weighted imaging (DWI)—that are important research tools in epilepsy that are rapidly developing and being applied to problems in clinical practice. The chapter also provides an overview of the underlying principles of these methods, some of the technical constraints involved, and methods of analysis along with their implications. Moreover, the chapter illustrates the application of these methods to patients with epilepsy followed by a discussion of potential future developments. Diffusion imaging has been applied both to the specific examination of the hippocampus in patients with temporal lobe epilepsy (TLE) and to the investigation of the brain as a whole in non-TLE patients. With the increasingly wide availability of MR scanners capable of acquiring such data in combination with the provision of software to calculate meaningful parameters, clinical utility may gradually be established.
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