Abstract

DNA damage occurs in the context of chromatin, and, of course, so do recognition and repair of the DNA lesions. It is well established that chromatin composition and dynamics play a central role in the cellular response to DNA damage and, in particular, to double-strand breaks (DSBs). Here, we review recent advances in the contribution of histone posttranslational modifications, histone variants, and chromatin remodeling enzymes to DSB responses.

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