Abstract
For many decades, the unprecedented concern in modifying drug delivery systems has been a prominent thrust of pharmaceutical research. Higher clinical development costs coupled with declining drug-discovery process and lower clinical success rates are negatively influencing the flow of new chemical entities in the research-and-development pipeline. In the words of La Van and Langer, “It is likely that the pharmaceutical industry will transition from a paradigm of drug discovery by screening compounds to the purposeful engineering of targeted molecules” [1]. The hunt for novel drug delivery approaches and newer modes of action is a rapidly progressing field. An important and long-term goal of the pharmaceutical industry is to explore therapeutic agents capable of selective delivery to specific areas in the body to take advantage of the therapeutic index. The “magic bullet” concept, first proposed by Paul Ehrlich in 1891, represents the first early account of the drug-targeting paradigm [2]. Nanomaterials due to their unique properties can be applied to various commercialized products including food, drug or cosmetics.
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