Abstract
Abstract Quadrupole time-of-flight (QTOF) tandem mass spectrometers (MSs) were first commercially available in the mid-1990s. Since then, they have traditionally been coupled with liquid chromatography (LC)-based ionization techniques, such as electrospray ionization and atmospheric pressure chemical ionization (APCI). More recently, QTOF instruments have been paired with gas chromatography (GC) via the modified APCI ion source; however, this technique utilizes an LC-based QTOF to couple to the gas chromatograph. Although this provides increased versatility for the LC–QTOF, its use is restricted to APCI ionization. This chapter discusses a novel QTOF instrument that has been specifically designed to be interfaced with GC using the primary GC/MS ionization techniques of electron ionization (EI) and chemical ionization (CI). This new coupling of EI and CI ionization techniques to QTOF technology expands the number and types of compounds that are currently analyzed by QTOF MSs. The basic principles of GC/QTOF technology and its use for environmental applications will be discussed.
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