Abstract
Leukocyte movement is a fundamental process that relies on actin cytoskeleton remodeling. Throughout this process, chemokine receptor signaling activates integrins that, together with adhesion molecules, anchor leukocytes to different types of substrates allowing them to move. During an immune response induced by pathogens or tissue damage, the bone marrow produces and mobilizes leukocytes on demand by sensing soluble instructive signals. Peripheral blood leukocytes and platelets are recruited to infected/damaged tissues to combat a given challenge. Antigen-presenting cells capture pathogens or antigens and migrate through the lymphatic circulation to the lymph nodes, and they encounter lymphoid cells that become activated and acquire specificity. After the noxious agent has been controlled, the immune response turns off, where lipid mediators inhibit leukocyte movement. This chapter will review the mounting of an immune response focusing on the molecules and main events to achieve leukocyte recruitment.
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