Abstract
Paget’s disease is a focal disorder of dysregulated bone turnover that was formerly common amongst older people, particularly those of western and southern European descent. In recent decades the prevalence has apparently fallen and newly presenting cases are older and have fewer bones involved. This suggests that in addition to the known genetic factors, there is an important (as yet unidentified) environmental factor in its etiology. Many patients with Paget’s disease are asymptomatic but well recognized complications include bone pain, deformity, fracture, and secondary osteoarthritis. Paget’s disease is usually diagnosed from its characteristic radiographic appearance. Bone scintigraphy is the best method of determining which bones are involved. Bone turnover markers are variably raised depending primarily on the extent of disease.
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