Abstract
Fifty nine patients with premature ejaculation (PE) received sertraline treatment for 8 weeks.The average intravaginal ejaculation latency time (IELT) and the scores of Chinese index of premature ejaculation (CIPE) were evaluated and the fasting serum leptin levels were measured before and after treatment,all the values were compared with those of 64 normal male controls.The serum leptin levels were higher,the IELT and CIPE scores were lower in PE patients than those in normal controls before treatment.After 8 weeks of treatment with sertraline,the levels of serum leptin in PE patients decreased to normal levels,CIPE and IELT increased.The results indicate that serum leptin can be used as a bioindicator for diagnosis of premature ejaculation and assessment of therapeutic efficacy in PE patients. Key words: Premature ejaculation; Leptin
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