Abstract
The immunoregulatory effects of intense exercise were examined measuring polymorphonuclear granulocyte (PMN) migration under agarose, lymphocyte proliferative responses after mitogen stimulation (phytohemagglutinin P, concanavalin A and pokeweed mitogen) and complement activation (C3 conversion) in the peripheral blood of elite runners undergoing maximal exertion. Eleven elite middle‐ and long‐distance runners were tested in a 5‐km race on a running track. PMN migration activity towards autologous serum and FMLP as chemoattractants both increased after intense physical activity. The lymphocytes showed increased proliferative responses to the mitogen stimulation 2 h after the run compared with pre‐exercise values, and normalized activity after 24 h. The total number of lymphocytes in the peripheral blood markedly decreased 2 h after the run and the number of leukocytes increased. A tendency to a decrease in complement C3 conversion‐was observed after the run, but within the estimated normal area. Our findings suggest that intense physical activity influences the cellular immune system.
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