Abstract
We tested the effects of injections of small doses of131I (150 μCi) into female rats on brain development in their offspring. The brains of rats whose embryogenesis was influenced by incorporated131I were studied with the use of an immunohistochemical technique (monoclonal antibodies to nuclear antigen of cell proliferation). Single injections of131I in the above dose were shown to noticeably suppress the cell proliferative activity in a few structures of the brain of newborn rats. The most significant drop in the proliferative index in the external layers of the cerebellum was observed after131I injections performed on the 16th day of embryogenesis (when the embryonal thyroid gland begins its functioning).
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