Abstract
The content of epidermal inhibitor of mitosis (G2 chalone) at different stages of the estrous cycle in rats was determined by the radial immunodiffusion method. The chalone level correlates with the mitotic index of the vaginal mucous membrane and is minimal in proestrus and maximal in estrus. In aging (14–16 months) rats with regular cycles the content of G2 chalone in the vaginal mucous membrane at all phases of the estrous cycle was significantly lower than in young (3–4 months) rats with a regular cycle. In castrated rats the mitotic index begins to rise 18 h after a single injection of estradiol benzoate (1 μg/100 g body weight). This increase is preceded by a significant decrease in the concentration of G2 chalone 12 h after injection of the estrogen.
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