Abstract
An attempt was made to assay the analgesic potency of d-amphetamine sulfate (0.5, 1.0, 2.0, 4.0 mg/kg) and α-methyl-p-tyrosine (75, 150, 225 mg/kg) in the rat using the spatial preference technique. Amphetamine in all doses tested significantly raised the aversive threshold while α-methyl-p-tyrosine demonstrated similar effects only with the 150 and 255 mg/kg dosages. These data were interpreted to suggest that α-MT raised the aversive threshold by mechanisms other than drug-induced sedation, while amphetamine produced similar results by a direct analgesic effect and/or by altering locomotor activity. It was suggested that intact adrenergic systems may be needed for animals to fully respond to the aversive qualities of electric shock.
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