Abstract
The aim. The objective of this study was to analyze effects of chronic heart failure (CHF) and obesity on systemic inflammatory and hemostatic response in patients with acute infective exacerbation of chronic obstructive pulmonary disease (COPD). Materials and methods . This cohort study involved 65 patients with infective acute exacerbation of chronic obstructive pulmonary disease (AECOPD) meeting 2 or 3 Anthonisen's criteria. Patients with ( n = 53) or without ( n = 12) co - morbid CHF and with ( n = 20) or without ( n = 25) co - morbid obesity were analyzed separately. Markers of systemic inflammation and hemostatic activation were measured. Results . Increased serum concentrations of C - reactive protein, IL - 6, endothelin - 1, von Willebrand factor, homocysteine, thrombin - antithrombin complex, plasminogen activator inhibitor type 1 were found in AECOPD patients of all subgroups; serum level of tissue factor pathway inhibitor (TFPI) was also increased. These proinflammatory and hypercoagulatory shifts were not related to CHF and obesity. Increased TNF - α level in blood was found only in CHF patients.
Highlights
plasminogen activator inhibitor type 1 were found in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients of all subgroups
hypercoagulatory shifts were not related to chronic heart failure (CHF) and obesity
1 го типа на фоне увеличения плазменного содержания ингибитора внешнего пути свертывания
Summary
А.Г.Чучалин 1, И.Я.Цеймах 2, А.П.Момот 2, 3, А.Н.Мамаев 3, 4, И.А.Карбышев 5, Г.И.Костюченко 4. Ляпидевского, 1; 4 – КГБУЗ "Краевая клиническая больница": 656024, Барнаул, ул. Ляпидевского, 1; 5 – Краевое ГБУЗ "Диагностический центр Алтайского края": 656038, Барнаул, Комсомольский пр т, 75а. Целью исследования явился анализ влияния хронической сердечной недостаточности (ХСН) и ожирения на показатели системных воспалительных и гемостатических реакций у больных с инфекционным обострением хронической обструктивной болезни легких (ХОБЛ). У больных с обострением ХОБЛ во всех подгруппах наблюдалось повышение показателей С реактивного белка, интерлейкина 6, плазменного содержания эндотелина 1, фактора Виллебранда, гомоцистеина, тромбин антитромбинового комплекса, ингибитора активатора плазминогена 1 го типа на фоне увеличения плазменного содержания ингибитора внешнего пути свертывания. – Federal Institution "Pulmonology Research Institute", Federal Medical and Biological Agency of Russia: 32, build. – State Institution "Altay State Medical University", Healthcare Ministry, Russia: 75, Zmeinogorskiy trakt, Barnaul, 656045, Russia;. – Altay branch of Federal State Budget Institution "Hematology Scientific center", Healthcare Ministry, Russia: 1, Lyapidevskogo ul., Barnaul, 656024, Russia; 4 – State Institution "Territorial Clinical Hospital": 1, Lyapidevskogo ul., Barnaul, 656024, Russia; 5 – Territorial State Institution "Diagnostic Center of Altay Territory": 75a, Komsomol'skiy prospekt, Barnaul, 656038, Russia
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