Changes in prostate-specific antigen doubling time (PSADT) prior to and after treatment with hormonal therapy (HT) in men with biochemically recurrent prostate cancer (BRPC): A preliminary analysis.

Abstract

e15188 Background: PSADT is an important prognostic parameter in all clinical states of PCA. Intra -subject changes in PSADT prior to and after HT remains undefined. Methods: Men with rising serum PSA levels after local therapy were longitudinally followed from the hormone-sensitive (HS) to the castration-resistant (CR) state. PSADT was calculated according to standard formulas ( Pound et al., JAMA 1999) and previously identified prognostic subgroups (Antonarakis et al., BJU Int 2012; Freedland et al., JCO 2007) were used to evaluate the potential clinical significance of PSADT according to the following subgroups: [1] < 3 months (mo); [2] 3-8.9 mo, [3] 9-14.9 mo, and [4] ≥ 15 mo). Results: 55 men with BRPC who eventually developed CR disease on HT were retrospectively analyzed. The median age of HS men was 60 y (range (r) 43-78); CR men 66 y (r 43-87). Of all men, 28 had prior surgery (S), 5 had radiation (R), 14 had S+R, 7 had neoadjuvant /adjuvant HT + local therapy, and 1 had no local therapy. PSADT in the CR state was shorter than PSADT in the HS state (signed –rank test; p=0 .012). HS men with PSADT < 4 m had shorter overall survival than those with PSADT ≥ 4 mo ( 13.9 vs. 20.1 mo; HR ; 8.46). Changes in PSADT from the HS to the CR state are summarized in the Table below. The majority of men converted from a more favorable to a less favorable PSADT subgroup as they progressed from HS to CR states. Conclusions: PSADT tends to shorten from the HS to the CR states. The prediction of clinical outcome based on PSADT needs to account for the clinical state the patient is in, as PSADT may change within the same patient from state to state. [Table: see text]