Abstract
ABSTRACTEthanol introduced into the organism undergoes rapid metabolism to acetaldehyde and then to acetic acid. The process is accompanied by formation of reactive oxygen species (ROS), which damage mainly lipids of membrane cells. The effects of ROS can be neutralized by administering preparations with antioxidant properties. The natural preparations of this kind are teas.This paper reports data on the effect of green and black tea on the surface charge density, content of phospholipids, and level of lipid peroxidation products of liver cell membrane of rats chronically intoxicated with ethanol. Surface charge density of liver cells was measured by the electrophoresis method, whereas qualitative phospholipid composition was determined by the HPLC method.Ethanol administration caused an increase in the amount of all phospholipids, in surface charge density as well as in lipid peroxidation products. Ingestion of green and black tea with ethanol partially prevented these ethanol-induced changes, and the action of green tea was stronger than that of black tea.
Highlights
About 90% of ethanol is oxidized in the liver, so acute and chronic ethanol intoxication is characterized by structural alterations of the liver cells
The above parameters characterizing PI, PS, PE, and PC increased by about 190%, 250%, 200%, and 200%, respectively, for the rats from the green tea part of the experiment and by about 170%, 260%, 150%, and 200%, respectively, for the rats from thee black tea part of the experiment
The increase was smaller by about 30%, 10%, 60%, and 70% in the amount of these phospholipids for the rats that were administered ethanol and black tea than for the rats that were administered ethanol and green tea, where it was by about 100%, 80%, 80%, and 100%, respectively, when compared with the ethanol groups
Summary
About 90% of ethanol is oxidized in the liver, so acute and chronic ethanol intoxication is characterized by structural alterations of the liver cells. There, ethanol is oxidized into acetaldehyde and into acetate; these processes are accompanied by free radical generation (Lieber 1997). As a consequence of ethanol intoxication, conducive changes in the properties of the liver, including cell membrane properties, take place. The biological membrane functions as a selective barrier and is essential for transport, ion permeability, enzyme activity, and receptor responsiveness (Gennis 1989). All of these membrane functions require structural integrity and the accurate electric properties, which may be modified by changes in membrane composition. Electric properties of the membrane depend on acid-base and complex formation equilibria between cell membrane components and the environmental components
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