Abstract
The purpose of this study was to assess the effect of antidepressant therapy on changes in instrumental activities of daily living disability in elderly female patients with musculoskeletal pain in a controlled study comparing active drugs with a placebo. In an 8-week double-blind, placebo-controlled outpatient trial, 30 female patients (response rate 90.0%) between 70 and 79 were examined. They all had a history of clinically evident musculoskeletal pain, were afflicted with depressive symptoms, and could independently bathe, walk, dress, and transfer (e.g., from a chair) inside the house. The study was performed using the Center for Epidemiological Studies Depression Scale (CES-D), and Instrumental Activities of Daily Living (IADL). Compared with the placebo-group, significant changes in the CES-D (p<0.01) and IADL (p<0.01) scales were observed after eight weeks in the active drug-treated subjects. Treatment of depressive symptoms may be efficacious in reducing IADL disability in elderly female patients afflicted with musculoskeletal pain.
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