Abstract
Hemomicrocirculatory bed (HMCB) in the modern sense is a complex organized system that provides ordered motion of blood, tissue fluids, absorption and excretion of biochemical substrates, metabolites, biologically active substances. Among the interrelated and interdependent processes in the system of HMCB, the main role belongs to the patterns of blood circulation in the vessels. The last decade has been marked by a completely new approach to solving problems associated with impaired blood filling. The use of tissue transplantation, in particular cryopreserved placenta grafts, as a corrective method, is quite effective. The latter was the basis for a comprehensive study of the ileal mucosa HMCB response to the cryopreserved placenta transplantation [11]. The aim of this study was to investigate the dynamics of the ileum mucosa hemo-microcirculatory bed parameters with a single administration of cryopreserved placenta and with the cryopreserved placenta administration against the background of acute aseptic experimental peritoneum inflammation in rats. Object and methods of the study. The object of the experimental study was the ileum wall sampled from 140 mature Wistar male rats. The animals were divided into four groups. Animals were euthanized on the 1st, 2nd, 3rd, 5th, 7th, 10th, 14th, 21st, 30th days. Measurements of the HMCB vessels internal diameter in the ileac mucosa were performed. The mathematical processing was performed by means of Student's t test (t). Differences at p <0.05 were considered reliable. Transplantation of cryopreserved placenta causes the reaction of all links of the hemomicrocirculatory bed by increasing their average diameter with maximum values for 5 days. Simulation of acute aseptic inflammation of the peritoneum initially led to a decrease in the diameter of arterioles by 5% and capillaries by 2.3%, by 2-3 days, and then by an increase in their diameters, by the 14th day of the study. During the experiment, the venular unit increased in diameter by the 14th day of the study. When transplanting cryopreserved placenta against acute aseptic inflammation of the peritoneum of the arterioles by 4% and capillaries by 2%, they first decrease in diameter by 2 days, and then increase in diameter by 3-10 days of the study. During the experiment, the venular unit significantly increased in diameter by the 14th day of the study. With the introduction of cryopreserved placenta on the background of acute aseptic inflammation of the peritoneum, the realization of inflammation decreased by 4-5 days.
Highlights
CHANGES IN HEMOMICROCIRCULATORY BED OF RAT ILEUM MUCOSA IN TRANSPLANTATION OF CRYOPRESERVED PLACENTA AGAINST THE BACKGROUND OF ACUTE ASEPTIC INFLAMMATION OF PERITONEUM*
The aim of this study was to investigate the dynamics of the ileum mucosa hemo-microcirculatory bed parameters with a single administration of cryopreserved placenta and with the cryopreserved placenta administration against the background of acute aseptic experimental peritoneum inflammation in rats
Transplantation of cryopreserved placenta causes the response of all the hemomicrocirculatory bed links by increasing their mean diameter with maximum parameters, and more advanced vasculature on the 5th day
Summary
CHANGES IN HEMOMICROCIRCULATORY BED OF RAT ILEUM MUCOSA IN TRANSPLANTATION OF CRYOPRESERVED PLACENTA AGAINST THE BACKGROUND OF ACUTE ASEPTIC INFLAMMATION OF PERITONEUM*. Моделювання гострого асептичного запалення очеревини спочатку призводило до зменшення в діаметрі артеріол на 5% і капілярів на 2.3%, на 2-3 доби, а потім збільшення їх діаметрів, на 14 добу дослідження. При трансплантації кріоконсервованої плаценти на тлі гострого асептичного запалення очеревини артеріоли на 4% і капіляри на 2% спочатку зменшуються в діаметрі на 2 добу, а потім збільшилися в діаметрі на 3-10 доби дослідження. When transplanting cryopreserved placenta against acute aseptic inflammation of the peritoneum of the arterioles by 4% and capillaries by 2%, they first decrease in diameter by 2 days, and increase in diameter by 3-10 days of the study. Among the interrelated and interdependent processes in the system of HMCB, the main role belongs to the patterns of blood circulation in vessels with diameters from 2 to 200 μm, the blood cells behavior, transcapillary exchange and ultrastructural features of microvessels [1, 2, 5, 7, 9]
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