Abstract
Total solute concentrations of the amniotic fluid and maternal plasma from 52 rhesus (Macaca mulatta) monkeys in various stages of pregnancy are reported. The mean amniotic fluid total solute concentration was 293.6 ± 7.0 mOsm. per kilogram of water from 40 to 90 days' gestation and 280.6 ± 4.7 mOsm. per kilogram of water from 90 to 158 days' gestation; and that of maternal plasma was 297.0 ± 6.6 mOsm. per kilogram throughout gestation.The relevance of these observations to the possible mechanism of formation of amniotic fluid is discussed.Total amniotic fluid volumes of ten animals at various gestational ages are reported. The volumes increased to a value of 20 ml. per kilogram of maternal weight at 112 days' gestation, and then decreased as pregnancy approached term.
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