Changes and significance of serum AchR-Ab and CAE-Ab in patients with thymoma after thoracoscopic surgery

Abstract

ABSTRACT To probe into the changes and significance of serum acetylcholine receptor antibody (AchR-Ab) and citric acid extractive antibody (CAE-Ab) in patients with thymoma after thoracoscopic surgery (TS). The data of 50 patients with thymoma receiving TS in our hospital from February 2017 to February 2021 were selected for retrospective analysis. Serological testing was performed before and after surgery to determine serum AchR-Ab and CAE-Ab levels, the therapeutic effect was evaluated and the trend of serum AchR-Ab and CAE-Ab changes and their meanings were analyzed. Among 50 patients with thymoma after TS, 15 (30.0%) were in remission, 25 (50.0%) had improvement and 10 (20.0%) had no response to treatment. After treatment, the serum AchR-Ab and CAE-Ab levels of patients, which were remarkably lower than those before treatment (P < 0.001), were remarkably lower in the remission group than in the improvement group (P < 0.001) and remarkably lower in the improvement group than in the ineffective group (P < 0.001). The ordinal logistic regression analysis concluded that the levels of AchR-Ab and CAE-Ab were related to therapeutic effect, i.e. the lower the serum AchR-Ab and CAE-Ab levels, the better the therapeutic effect. TS can reduce the serum AchR-Ab and CAE-Ab levels in patients with thymoma, and serum AchR-Ab and CAE-Ab levels can reflect the therapeutic effect, providing reference value.