Abstract
Objective To observe the change of cyclin-dependent kinase 5(Cdk5)in infra-limbie cortex in the early of conditioned fear extinction retention.Methods Fifty-six male adult SD rats were randomly divided into extinction group,sham extinction group and naive group.Conditioned fear model of rats was established by tone paired foot shock.Fear extinction was trained in 24 hours after establishment of fear memory.For extinction group and sham extinction group,retention test and immunnohistochemistry of Cdk5 were done at 2nd,4th and 8th day after fear.Results(1)Retention scores of extinction group and sham extinction group were worse than naive group at 2nd and 4th days after fear(P＜0.01),the scores of extinction group(71.04±11.65)and naive group were better than sham extinction group(35.48±12.37,P＜0.01)at 8th day after fear.(2)Cdk5 in IL of sham extinction group increased at 2nd day after fear(429±70,P＜0.05),the expression of extinction group's Cdk5 deereasod at 4th day after fear(208±30,P＜0.01),but it returned to normal at 8th day after fear.Conclusion The expression of Cdk5 in IL may increase after conditioned fear,but extinction may reduce its expression,which may be good for the early of conditioned fear extinction retention. Key words: Medial prefrontal cortex; Infra-limbic cortex; Cyclin-dependent kinase 5; Fear extinction
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Chinese Journal of Behavioral Medicine and Brain Science
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
