Abstract
The concentration of albumin in serum, the level of expression of albumin mRNA, polysome profiles and peptide synthesis activity in the liver were investigated in order to assess the level of protein synthesis in rats fed either a high phosphorus diet containing 1.5% phosphorus or a control diet containing 0.5% phosphorus for 3 weeks. In the rats fed the high phosphorus diet, body weight gain, food efficiency and serum albumin concentration decreased, and the albumin/globulin ratio also decreased compared with the control group. A low level of albumin mRNA expression was observed, consistent with the decrease in serum albumin concentration. The peptide synthesis activity in liver as determined in vitro was lower in the group fed the high phosphorus diet than in the control group. The abundance of heavier polysomes considered to influence protein synthesis in vivo was decreased in the rats given the high phosphorus diet compared with the control group. The results suggest that high phosphorus intake caused a decrease in protein synthesis in liver.
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