Abstract
Skincare is very critical in preventing aging and skin trouble, which is difficult to recover if progressed. However, the development of effective anti-aging solutions is still on the horizon. The purpose of this study was to evaluate the functional efficacy of Ceriporia lacerata exo-pharmaceutical substance (CLEPS) in view of its use in innovative skin care cosmetics. CLEPS was found to have no cytotoxicity against normal human dermal fibroblasts and B16 melanoma cells in a wide concentration range of 0.05–7 mg/mL. It exhibited a whitening effect by inhibiting melanin synthesis comparable to that of the respective reference compound (arbutin). Notably, CLEPS not only substantially increased collagen (65.4%) and filaggrin synthesis (36%), but also significantly inhibited the activity of collagenase (93.4%), suggesting that CLEPS could prevent skin barrier damage or skin wrinkles. In addition, it showed an excellent anti-inflammatory effect and wound-healing effect. Overall, CLEPS exhibited exceptional anti-aging effects in human skin cells, designating as a potential natural cosmeceutical ingredient.
Highlights
TungmunnithumAmong other organs, human skin is a vanguard interface constantly exposed to harmful external stimuli, such as general metabolic reactions, cosmetics, and ultraviolet (UV) irradiation
The strain used in this experiment was used by inoculating C. lacerata mycelium (CLM) (FugenCellTech, TheKorea) strain on used in this experiment was used by inoculating
Our findings indicated that the Ceriporia lacerata exo-pharmaceutical substance (CLEPS) as a new skincare solution exerts a potential cosmeceutical effect on human skin cell aging through anti-oxidation, anti-inflammation, anti-breakdown of skin barrier, and wound healing
Summary
Human skin is a vanguard interface constantly exposed to harmful external stimuli, such as general metabolic reactions, cosmetics, and ultraviolet (UV) irradiation. These factors lead to undesired biochemical byproducts, including reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and advanced glycation end-products (AGEs), which can trigger skin aging, including wrinkles, pigmentation, and loss of skin tone [1,2]. The formation of AGEs is the result of the reaction of glucose with proteins, including skin collagen, which can contribute to loss of elasticity, wrinkles, inflammation, inhibition of skin cell growth, and accelerated aging [2]. Antioxidants can be beneficial to the human body by directly or indirectly neutralizing ROS, via regulating metabolic pathways and gene expression as the main cellular activation mechanisms
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