Abstract
Several neurochemical abnormalities are known in dementia of Alzheimer type (DAT). Little is known about the neurochemical changes in dementia with frontotemporal cortical degeneration of non-Alzheimer type (FTD), including Pick's disease. The present study evaluates the cerebrospinal fluid (CSF) levels of neuropeptide Y-like immunoreactivity (NPY-LI) correlated with duration of the disease. There was a significant difference between NPY-LI in DAT and FTD. NPY-LI is reduced in DAT but not in FTD. In FTD the CSF levels of NPY-LI tended to increase with the duration of the disease while in DAT the NPY-LI levels tended to decrease. This points towards a different involvement of NPY neurons in these two types of primary degenerative dementias.
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